ExplanationIntermediate
What mechanisms do bacteria use to develop resistance to aminoglycosides according to Talaro and Chess?
Bacteria develop resistance to aminoglycosides primarily through changes in drug permeability due to point mutations in proteins of the transport system or outer membrane.
Aminoglycoside resistance in bacteria is primarily developed through changes in drug permeability. This resistance mechanism involves point mutations in the proteins of the transport system or the outer membrane of the bacterial cell. These mutations alter the permeability of the bacterial cell to the drug, thereby reducing its effectiveness.
Key points
- Aminoglycoside resistance is linked to changes in drug permeability.
- Point mutations in transport system proteins or outer membrane are responsible.
- These mutations reduce the drug's ability to enter the bacterial cell.
Source:Talaro's Foundations in Microbiology· Drugs, Microbes, Host—The Elements of Chemotherapy· p. 405–408
Talaro's Foundations in Microbiology
Kathleen Park Talaro
EIGHTH EDITION · McGraw-Hill, a business unit of The McGraw-Hill Companies, Inc.